Mikan Sakura follows her bestfriend, the ever-stoic Hotaru Imai to the prestigious Gakuen Alice, where all students has their own super special powers called Alice.Once the Class 2-B adviser,Narumi, finds out and confirms that Mikan has an Alice, she was able to attend the Academy and stay with her friend. Challenges would block Mikan and her newly found friends and strong ties will help them oversome the wraths of the Anti-Alice Oragnization.